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KMID : 0900220180250020091
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대한비과학회지
2018 Volume.25 No. 2 p.91 ~ p.98
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The Relationship between the Causative Allergens of Allergic Diseases and Environments in Korea Over a 8-Year-Period: Based on Skin Prick Test from 2006 to 2015
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Park Chan-Soon
Kim Boo-Young
Kim Soo-Whan
Lee Joo-hyung
Koo Soo-Kweon
Kim Kyung-Su
Kim Seon-Tae
Kim Yong-Dae
Kim Jeong-Hong
Kim Jin-Kook
Kim Chang-Hoon
Kim Hyun-Jun
Kim Hyo-Yeol
Rha Ki-Sang
Roh Hwan-Jung
Park Dong-Joon
Shin Seung-Heon
Lim Sang-Chul
Lee Jae-Hoon
Lee Heung-Man
Lee Heung-Gu
Kim Young-Ha
Cho Jin-Hee
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Abstract
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Background and Objectives: The present study evaluated the results of skin prick test using 55 allergens at 20 centers in the Republic of Korea in 2006, 2010, and 2014-2015. The aim was to assess changes in the positive rate of allergens according to temporal, regional, and environmental factors.
Materials and Method: In total, 20 hospitals were selected based on the population distribution in the Republic of Korea. A skin prick test panel comprising 55 aeroallergens was distributed to 18 hospitals for this prospective study. The 2006 and 2010 skin prick test results were collected and analyzed retrospectively from 20 hospitals, while the 2014/2015 skin prick test results (from June 2014 to May 2015) were collected prospectively from 18 hospitals.
Results: A total of 14,897 SPT test results were analyzed: 4,319 in 2006, 7,431 in 2010, and 1,852 in 2014/2015. The overall rate of skin prick test positivity to more than two allergens was significantly higher in males than females. The positive rates of alder pollens and birch, oak and ragweed pollen positivity were increased in older patients. Several positive rates were increased according to the temperature in spring. The positive rates for beech pollen, birch pollen, hazel pollen, oak pollen, Tyrophagus putrescentiae, mugwort, cat, Acarus siro, Lepidoglyphus destructor and Tyrophagus putrescentiae were significantly increased, while those of Cult rye pollen and dandelion were significantly decreased over the three test periods. The overall positive rate for allergens in Jeju province varied significantly from Seoul and other cities.
Conclusion: Change in the positive rate of multiple aeroallergens was evaluated in the Republic of Korea over time. Our findings can be used to recommend aeroallergens suitable for inclusion in skin prick test panels in the Republic of Korea and will facilitate further investigation of changes in the patterns of allergic diseases.
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KEYWORD
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Skin prick test, Aeroallergen
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